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KMID : 0383119910390010097
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Journal of Aerospace Medicine
1991 Volume.39 No. 1 p.97 ~ p.110
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Effects of Positive Acceleration on Atrial Natriuretic Peptide(ANP)
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Park Jong-Kwan
Seo Man-Wook
Seul Kyung-Hwan
Cho Kyung-Woo
Park Byoung-Ok
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Abstract
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From the Department of Urology, Aeromedical Training Center , RPKAF, and Surgeon General Office ROKAF and Department of Physiology, Chonbuk National University, Medical College, Chonju, Korea Hypergravity has been shown to affect the human body, especially the heart and kidney, On positive acceleration, circulating blood volume to the heart is decreased because some blood is accumulated on the peripheral organs. Atrial natriuretic peptide is a peptide hormone that is synthesized and stored in atrial myocytes and released, when blood volume on the atrium is increased. Plsma renin activity is increased, when renal blood flow is decreased by positive acceleration. ANP has inverse relationship with renin, which has sodium and water retention. The experiment was designed to investigate possible ANP decrease and reverse relationship with PRA after exposure to 6G for 30 secs positive acceleration force as imposed on human by the Human Centrifuge. As results, positive radial acceleration has made decreasing of plasma ANP in statistically with increasing PRA.
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